Studies on Cytotoxic Constituents in Pericarps of Mallotus japonicus, Part II

Two new phloroglucinol derivatives, mallotolerin (8) and mallotochromanol (9), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-me thy l-6- methoxybenxyl)-phlorbutyrop...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1986-03, Vol.49 (2), p.298-302
Main Authors: Arisawa, Munehisa, Fujita, Akio, Saga, Manabu, Hayashi, Toshimitsu, Morita, Naokata, Kawano, Nobusuke, Koshimura, Saburo
Format: Article
Language:English
Subjects:
Acetylation
Animals
Antineoplastic Agents, Phytogenic - analysis
Antineoplastic Agents, Phytogenic - pharmacology
Carcinoma, Ehrlich Tumor - pathology
Cell Division - drug effects
Cell Line
Chemical Phenomena
Chemistry
Chromatography, Ion Exchange
Male
Mice
Mice, Inbred Strains
Plants, Medicinal - analysis
Spectrophotometry, Ultraviolet
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Summary:Two new phloroglucinol derivatives, mallotolerin (8) and mallotochromanol (9), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-me thy l-6- methoxybenxyl)-phlorbutyrophenone (8) and 8-acetyl-5,7-dihydroxy-6-(3-acetyl-2,4-dihydroxy-5-methyl-6- methoxybenxyl)2,2-dimethyl-3-hydroxychroman (9) by their respective chemical and spectral data. These compounds were found to be cytotoxic against KB and L-5178Y cell lines in culture and to be moderately effective in inhibiting the growth of Ehrlich carcinoma in mice. Cytotoxic activities of the isolated phloroglucinol derivatives (1-9) from the pericarps are also discussed.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50044a016