Defense reactions of mosquitoes to filarial worms: effect of host age on the immune response to Dirofilaria immitis microfilariae

The melanization response of Aedes aegypti black-eyed Liverpool strain (LVP) and Aedes trivittatus against intrathoracically inoculated Dirofilaria immitis microfilariae (mff) was assessed in mosquitoes < 1, 14, 21, and 28 days after adult ecdysis. There was a significant decrease in the melaniza...

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Bibliographic Details
Published in:The Journal of parasitology 1986-04, Vol.72 (2), p.212-215
Main Authors: Christensen, B.M, LaFond, M.M, Christensen, L.A
Format: Article
Language:English
Subjects:
AEDES
Aedes - immunology
Aedes - metabolism
Aedes - parasitology
AEDES AEGYPTI
AEDES TRIVITTATUS
AGE
Aging
Animals
Blood
DIROFILARIA
Dirofilaria immitis - immunology
Dirofilaria immitis - parasitology
EDAD
Filarioidea - parasitology
Hemocytes
Host-Parasite Interactions
IMMUNE RESPONSE
Immunology
Insect Vectors - immunology
Insect Vectors - metabolism
Insect Vectors - parasitology
LARVAE
LARVAS
LARVE
Melanin
Melanins - metabolism
Melanization
MELANIZATION RESPONSE
Microfilariae
Microfilariae - immunology
Microfilariae - parasitology
Mosquitos
NEMATODE
NEMATODES
NEMATODOS
Parasite hosts
Parasites
Parasitology
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
VECTEUR
VECTORES
VECTORS
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Summary:The melanization response of Aedes aegypti black-eyed Liverpool strain (LVP) and Aedes trivittatus against intrathoracically inoculated Dirofilaria immitis microfilariae (mff) was assessed in mosquitoes < 1, 14, 21, and 28 days after adult ecdysis. There was a significant decrease in the melanization response of A. aegypti 14 days of age and older at 1, 3, and 5 days postinoculation (PI) compared to < 1-day-old mosquitoes. The response also was reduced significantly in 14- to 28-day-old A. trivittatus on days 1 and 3 PI. Although essentially 100% of recovered mff were melanized by day 5 PI in A. trivittatus, the amount of melanin deposited was much less than that seen in 0-day-old mosquitoes. Potential mechanisms responsible for a reduced immune competence in older mosquitoes and the possible relationship to vector potential are discussed.
ISSN:0022-3395
1937-2345
DOI:10.2307/3281593