Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities

Objective: To determine whether placental lesions are risk factors for neurologic morbidities in intrauterine growth restricted (IUGR) infants, we compared the incidence of cranial ultrasound (CUS) abnormalities and the number and type of placental lesions in IUGR cases and gestational age-matched a...

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Bibliographic Details
Published in:Early human development 2001-04, Vol.62 (1), p.1-10
Main Authors: Viscardi, Rose M, Sun, Chen-Chih J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Cerebral Infarction - diagnostic imaging
Cerebral Infarction - epidemiology
Cerebral Infarction - etiology
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - epidemiology
Cerebrovascular Disorders - etiology
Diseases of mother, fetus and pregnancy
Female
Fetal Growth Retardation - epidemiology
Fetal Growth Retardation - etiology
Fetal Growth Retardation - pathology
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Intracranial Hemorrhages - diagnostic imaging
Intracranial Hemorrhages - epidemiology
Intracranial Hemorrhages - etiology
Intrauterine growth retardation
Intraventricular hemorrhage
Leukomalacia, Periventricular - diagnostic imaging
Leukomalacia, Periventricular - epidemiology
Leukomalacia, Periventricular - etiology
Medical sciences
Placenta Diseases - complications
Placenta Diseases - epidemiology
Placenta Diseases - pathology
Placental pathology
Pregnancy
Pregnancy. Fetus. Placenta
Retrospective Studies
Risk Factors
Ultrasonography
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Summary:Objective: To determine whether placental lesions are risk factors for neurologic morbidities in intrauterine growth restricted (IUGR) infants, we compared the incidence of cranial ultrasound (CUS) abnormalities and the number and type of placental lesions in IUGR cases and gestational age-matched appropriate for gestational age (AGA) controls. Study design: Retrospective case-control study of 94 singleton IUGR and 145 AGA infants. Medical records, CUS reports, and placental histology were reviewed. Analyses included χ 2, t-test, analysis of variance and logistic regressions to identify those variables significantly associated with IUGR and those associated with CUS abnormalities. Results: The incidence of CUS abnormalities was 1.7-fold higher in IUGR cases (50%) than controls (29.7%) ( p
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(01)00114-1