Neuropsychiatric Symptoms of Patients With Progressive Supranuclear Palsy and Parkinson's Disease

Neuropsychiatric symptoms are common in basal ganglia disorders and may have severe clinical consequences. The authors compared the neuropsychiatric manifestations of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). All 103 PD patients and 27 of the 61 PSP patien...

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Bibliographic Details
Published in:The Journal of neuropsychiatry and clinical neurosciences 2001, Vol.13 (1), p.42-49
Main Authors: Aarsland, Dag, Litvan, Irene, Larsen, Jan P
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Basal Ganglia - physiopathology
Biological and medical sciences
Brain Mapping
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Delusions - diagnosis
Delusions - physiopathology
Delusions - psychology
Dementia - diagnosis
Dementia - physiopathology
Dementia - psychology
Female
Frontal Lobe - physiology
Hallucinations - diagnosis
Hallucinations - physiopathology
Hallucinations - psychology
Humans
Male
Medical sciences
Middle Aged
Motivation
Neural Inhibition - physiology
Neurology
Neuropsychological Tests
Neurotransmitter Agents - physiology
Parkinson Disease - diagnosis
Parkinson Disease - physiopathology
Parkinson Disease - psychology
Supranuclear Palsy, Progressive - diagnosis
Supranuclear Palsy, Progressive - physiopathology
Supranuclear Palsy, Progressive - psychology
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Description
Summary:Neuropsychiatric symptoms are common in basal ganglia disorders and may have severe clinical consequences. The authors compared the neuropsychiatric manifestations of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). All 103 PD patients and 27 of the 61 PSP patients were taking dopaminergic agents. PSP patients showed significantly more apathy and disinhibition. Patients with PD had higher frequency of hallucinations, delusions, and depression. These results suggest that PSP patients show symptoms compatible with lesioned orbitofrontal and medial frontal circuits, such as disinhibition and apathy, whereas PD patients show symptoms associated with monoaminergic disturbances, such as psychosis and depression.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.13.1.42