Carbohydrate metabolism during long-term growth hormone treatment in children with short stature born small for gestational age

• Published in: Clinical endocrinology (Oxford) 2001-02, Vol.54 (2), p.243-251
• Main Authors: Sas, Theo, Mulder, Paul, Aanstoot, Henk Jan, Houdijk, Mieke, Jansen, Maarten, Reeser, Maarten, Hokken-Koelega, Anita
• Format: Article
• Language: English
• Subjects: Area Under Curve; Biological and medical sciences; Blood Glucose - metabolism; Body Mass Index; Carbohydrate Metabolism; Child; Double-Blind Method; Drug Administration Schedule; Drug toxicity and drugs side effects treatment; Female; Glucose Tolerance Test; Glycated Hemoglobin A - analysis; Growth Disorders - drug therapy; Growth Disorders - metabolism; Growth Hormone - administration & dosage; Growth Hormone - therapeutic use; Human Growth Hormone - administration & dosage; Human Growth Hormone - therapeutic use; Humans; Infant, Newborn; Infant, Small for Gestational Age - metabolism; Insulin - blood; Male; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Pharmacology. Drug treatments
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1046/j.1365-2265.2001.01178.x

OBJECTIVE To assess possible side‐effects of long‐term continuous growth hormone (GH) treatment on carbohydrate (CH) metabolism in children with short stature born small for gestational age. DESIGN In a prospective, randomised double‐blind, dose–response multicentre trial, the effect of GH treatment on CH metabolism was evaluated, comparing two GH dosages [3 vs. 6 IU/(m2 body surface·day)]. PATIENTS Seventy‐eight children with short stature (height SD‐score