Blood viscosity, hemodynamics and vascular hindrance in a rat model of acute controlled bleeding and volume restitution with blood or Haemaccel

Background: Hemorrhage and volume restitution with commercially available solutions is followed by reduced blood viscosity. Consequent hemodynamic changes may arise not only from the reduced viscosity itself but also from changes in vascular geometry induced by autoregulation processes. Vascular hin...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2001-03, Vol.45 (3), p.371-376
Main Authors: Hilzenrat, N., Arish, A., Yaari, A., Almog, Y., Sikuler, E.
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood Viscosity
Blood Volume
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Controlled bleeding
Haemaccel
Hematocrit
hemodilution
Hemodynamics
Male
Medical sciences
Plasma Substitutes - therapeutic use
Polygeline - therapeutic use
radioactive microspheres
Rats
Rats, Sprague-Dawley
Shock - blood
Shock - physiopathology
Shock - therapy
Splanchnic Circulation
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
vascular hindrance
Vascular Resistance
viscosity
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Summary:Background: Hemorrhage and volume restitution with commercially available solutions is followed by reduced blood viscosity. Consequent hemodynamic changes may arise not only from the reduced viscosity itself but also from changes in vascular geometry induced by autoregulation processes. Vascular hindrance reflects the contribution of vascular geometry to flow. Our aim was to explore the possible effects of blood volume restitution with Haemaccel or blood, on regional blood flow and vascular geometry. Methods: Under ketamine anesthesia, blood was withdrawn at a rate of 0.3 ml/min for 15 min followed by 15 min of stabilization. The shed blood or Haemaccel was infused at the same rate and volume as used for withdrawal. Hemodynamic measurements were performed using radioactive microspheres. Blood viscosity was measured with an Ostwald viscometer. Vascular hindrance was calculated as the resistance/viscosity ratio. Results: Volume replacement with Haemaccel (n=10), compared to blood (n=10), was followed by increased cardiac output and portal venous inflow (37.1±9.0 and 3.1±0.5 vs 25.9±6.8 and 2.2±0.9 ml · min−1 · 100 g bw−1, respectively; P
ISSN:0001-5172
1399-6576
DOI:10.1034/j.1399-6576.2001.045003371.x