Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome

Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of a quaporin-5, ry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of a quaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-03, Vol.357 (9257), p.688-689
Main Authors: Tsubota, Kazuo, Hirai, Shinichiro, King, Landon S, Agre, Peter, Ishida, Naruhiro
Format: Article
Language:English
Subjects:
Aquaporin 5
Aquaporins - metabolism
Biological and medical sciences
Cells
Cytoplasm - metabolism
Disease
Eyes & eyesight
Humans
Investigative techniques, diagnostic techniques (general aspects)
Lacrimal Apparatus - metabolism
Medical research
Medical sciences
Membrane Proteins
Membranes
Ophthalmology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Protein synthesis
Proteins
Sjogren's Syndrome - metabolism
Sodium
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Summary:Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of a quaporin-5, ry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of a quaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients. (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)04140-4