Elevated plasma nitrate levels in depressive states

Background: Previous studies have shown that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, suggesting that NO is involved in the pathogenesis of depression. The purpose of this study is to examine whether or not NO production increases in depressed patients....

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Bibliographic Details
Published in:Journal of affective disorders 2001-03, Vol.63 (1), p.221-224
Main Authors: Suzuki, Eiji, Yagi, Gohei, Nakaki, Toshio, Kanba, Shigenobu, Asai, Masahiro
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders
Anxiety Disorders - physiopathology
Biological and medical sciences
Biomarkers - analysis
Depression
Depression - physiopathology
Female
Humans
Male
Medical sciences
Mood disorders
Nitrate
Nitrates - blood
Nitrates - metabolism
Nitric oxide
Nitric Oxide - biosynthesis
Nitric Oxide - blood
Nitrite
Plasma
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Background: Previous studies have shown that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, suggesting that NO is involved in the pathogenesis of depression. The purpose of this study is to examine whether or not NO production increases in depressed patients. Methods: Plasma nitrate concentrations, an index of NO production, were measured by high-performance liquid chromatography in depressed patients ( n=17) and compared with patients suffering anxiety ( n=6) and with healthy controls ( n=12). Results: Plasma nitrate concentrations were significantly higher in depressed patients than in patients with an anxiety disorder ( P
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(00)00164-6