Anti-α-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome

alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS. We performed immunoblot analysis of sera from 7 patients with childhood primary SS us...

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Published in:Journal of rheumatology 2001-02, Vol.28 (2), p.363-365
Main Authors: KOBAYASHI, Ichiro, KAWAMURA, Nobuaki, OKANO, Motohiko, SHIKANO, Takaaki, MIZUMOTO, Masahiko, HAYASHI, Yoshio, KOBAYASHI, Kunihiko
Format: Article
Language:English
Subjects:
Adolescent
Autoantibodies - blood
Biological and medical sciences
Biomarkers - blood
Carrier Proteins - blood
Carrier Proteins - immunology
Child
Female
Humans
Immunoblotting
Male
Medical sciences
Microfilament Proteins - blood
Microfilament Proteins - immunology
Recombinant Fusion Proteins
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sjogren's Syndrome - blood
Sjogren's Syndrome - immunology
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container_end_page 365
container_issue 2
container_start_page 363
container_title Journal of rheumatology
container_volume 28
creator KOBAYASHI, Ichiro
KAWAMURA, Nobuaki
OKANO, Motohiko
SHIKANO, Takaaki
MIZUMOTO, Masahiko
HAYASHI, Yoshio
KOBAYASHI, Kunihiko
description alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS. We performed immunoblot analysis of sera from 7 patients with childhood primary SS using glutathione-S-transferase alpha-fodrin fusion protein as an antigen. Anti-alpha-fodrin antibody was detected in sera from all 7 patients with childhood primary SS, 2 of 4 with secondary SS, and one of 7 with systemic lupus erythematosus, but in no other healthy controls. The anti-alpha-fodrin autoantibody was detected before anti-SSA or SSB antibody became positive; thus anti-alpha-fodrin antibody could be a useful marker for the early diagnosis of SS.
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source Medical Journals (Open access)
subjects Adolescent
Autoantibodies - blood
Biological and medical sciences
Biomarkers - blood
Carrier Proteins - blood
Carrier Proteins - immunology
Child
Female
Humans
Immunoblotting
Male
Medical sciences
Microfilament Proteins - blood
Microfilament Proteins - immunology
Recombinant Fusion Proteins
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sjogren's Syndrome - blood
Sjogren's Syndrome - immunology
title Anti-α-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome
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