On glomerular structural alterations in type-1 diabetes : Companions of early diabetic glomerulopathy

• Published in: Virchows Archiv : an international journal of pathology 2001-02, Vol.438 (2), p.129-135
• Main Authors: ØSTERBY, Ruth, BANGSTAD, Hans-Jacob, NYBERG, Gudrun, RUDBERG, Susanne
• Format: Article
• Language: English
• Subjects: Adult; Albuminuria; Associated diseases and complications; Biological and medical sciences; Capillaries - diagnostic imaging; Capillaries - metabolism; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - pathology; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - pathology; Enalapril - therapeutic use; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Extracellular Matrix - metabolism; Extracellular Matrix - ultrastructure; Female; Humans; Insulin - therapeutic use; Insulin Infusion Systems; Kidney Glomerulus - blood supply; Kidney Glomerulus - metabolism; Kidney Glomerulus - ultrastructure; Male; Medical sciences; Metoprolol - therapeutic use; Microscopy, Electron; Treatment Outcome; Ultrasonography
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s004280000311

Glomerular structural modifications were measured in kidney biopsies from two follow-up studies in type-1 diabetic patients with microalbuminuria and in kidney donors. Stereologic methods were used to obtain data on glomerular composition and absolute quantities per glomerulus to supplement data on diabetic glomerulopathy previously published. Diabetic patients at baseline (n=37) showed significant changes compared with controls (n=11). The volume fraction of tuft/glomerulus was increased, the proportion of capillary surface facing peripheral basement membrane was decreased (0.72+/-0.04 vs 0.77+/-0.03, P=0.0008), the ratio of mesangial surfaces, urinary/capillary, was decreased (0.67+/-0.17 vs 1.11+/-0.28, P