Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma

We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer. Oral administration of berberine for 14 days significantly inhibited the spontaneous mediastinal lymph node me...

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Bibliographic Details
Published in:Cancer letters 2001-04, Vol.165 (1), p.35-42
Main Authors: Mitani, Noriyasu, Murakami, Koji, Yamaura, Takeshi, Ikeda, Takashi, Saiki, Ikuo
Format: Article
Language:English
Subjects:
7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin (CPT-11)
Activator protein-1 (AP-1)
Animals
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Berberine
Berberine - therapeutic use
Biological and medical sciences
Camptothecin - analogs & derivatives
Camptothecin - therapeutic use
Carcinogenesis, carcinogens and anticarcinogens
Carcinoma, Lewis Lung - prevention & control
Carcinoma, Lewis Lung - secondary
Chemical agents
Disease Models, Animal
Female
Irinotecan
Lewis lung carcinoma
Lung Neoplasms - pathology
Lung Neoplasms - prevention & control
Lymph node metastasis
Lymphatic Metastasis
Mediastinal Neoplasms - prevention & control
Medical sciences
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness - prevention & control
Neoplasm Transplantation
Transcription Factor AP-1 - antagonists & inhibitors
Tumors
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Summary:We examined the effect of berberine, a major component with anti-fungal properties contained in Coptidis Rhizoma and Phellodendri Cortex, on the lymph node metastasis of murine lung cancer. Oral administration of berberine for 14 days significantly inhibited the spontaneous mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma (LLC) into the lung parenchyma in a dose-dependent manner, but did not affect the tumor growth at the implantation site of the lung. Combined treatment with berberine and an anti-cancer drug, CPT-11, resulted in a marked inhibition of tumor growth at the implantation site and of lymphatic metastasis, as compared with either treatment alone. Anti-activator protein-1 (anti-AP-1) transcriptional activity of non-cytotoxic concentrations of berberine caused the inhibition of the invasiveness of LLC cells through the repression of expression of urokinase-type plasminogen activator (u-PA).
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00710-2