Assessment of Gastric Acidity of Japanese Subjects over the Last 15 Years

The gastric acidity of young to elderly Japanese subjects from 1989 to 1999 was assessed and compared with that obtained in 1984, using GA-Test capsules containing acid-dissolving granules of riboflavin. The percentage of achlorhydric subjects increased with age as observed before, however, an over...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2001, Vol.24(3), pp.313-315
Main Authors: MORIHARA, Motohiko, AOYAGI, Nobuo, KANIWA, Nahoko, KOJIMA, Shigeo, OGATA, Hiroyasu
Format: Article
Language:English
Subjects:
achlorhydria
Achlorhydria - epidemiology
Adolescent
Adult
Aged
Aged, 80 and over
Aging - physiology
bioavailability
Biological and medical sciences
Female
GA Test capsule
Gastric Acid - physiology
gastric acidity
Gastric Acidity Determination
General pharmacology
Helicobacter pylori
Humans
Japan
Japanese elderly
Male
Medical sciences
Middle Aged
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Reference Values
Stomach - microbiology
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Summary:The gastric acidity of young to elderly Japanese subjects from 1989 to 1999 was assessed and compared with that obtained in 1984, using GA-Test capsules containing acid-dissolving granules of riboflavin. The percentage of achlorhydric subjects increased with age as observed before, however, an over all decrease in all age categories year by year was noted. The percentage of achlorhydric subjects aged 50 years in 1995—1999 was about 40%, which was lower than that (60%) in 1984. However, such a chronological change was not observed when the percentage of achlorhydric subjects was determined according to birth year, indicating that it is related to the birth year of subjects. The percentage of achlorhydric subjects correlated with infection by Helicobacter pylori. Considering the high percentage of achlorhydric elderly, bioavailability and bioequivalence studies should be performed taking into consideration the effects of gastric acidity on the in vivo performance of drug products.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.24.313