Tumour angiogenesis and Ki‐67 expression in phaeochromocytoma

Objective To determine the expression of CD34 (to evaluate vascularity) and Ki‐67 (as a proliferative index) in a variety of phaeochromocytomas and thus assess the utility of these markers as possible predictors of malignancy. Patients and methods Deparaffinized tissue sections from 21 patients with...

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Bibliographic Details
Published in:BJU international 2001-03, Vol.87 (4), p.381-385
Main Authors: Ohji, H., Sasagawa, I., Iciyanagi, O., Suzuki, Y., Nakada, T.
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - blood supply
Adult
Aged
Aged, 80 and over
angiogenesis
Biological and medical sciences
CD34
Female
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Male
Medical sciences
MIB‐1
Microcirculation
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neovascularization, Pathologic - diagnosis
phaeochromocytoma
Pheochromocytoma - blood supply
prognosis
Tumors
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Summary:Objective To determine the expression of CD34 (to evaluate vascularity) and Ki‐67 (as a proliferative index) in a variety of phaeochromocytomas and thus assess the utility of these markers as possible predictors of malignancy. Patients and methods Deparaffinized tissue sections from 21 patients with benign and four with malignant phaeochromocytoma were assessed immunohistochemically to evaluate microvascular counts (using CD34 antigen) and the proliferative index (Ki‐67 antigen, monoclonal antibody MIB‐1). Results There was no statistical association between high microvascular counts and malignancy, but there was between the MIB‐1 score and malignancy (P 
ISSN:1464-4096
1464-410X
DOI:10.1046/j.1464-410x.2001.00102.x