Endothelial Dysfunction and Salt-Sensitive Hypertension in Spontaneously Diabetic Goto-Kakizaki Rats

Endothelial dysfunction is associated with hypertension, hypercholesterolemia, and heart failure. We tested the hypothesis that spontaneously diabetic Goto-Kakizaki (GK) rats, a model for type 2 diabetes, exhibit endothelial dysfunction. Rats also received a high-sodium diet (6% NaCl [wt/wt]) and ch...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-02, Vol.37 (2, Part 2 Suppl), p.433-439
Main Authors: Cheng, Zhong Jian, Vaskonen, Timo, Tikkanen, Ilkka, Nurminen, Kaisa, Ruskoaho, Heikki, Vapaatalo, Heikki, Muller, Dominik, Park, Joon-Keun, Luft, Friedrich C, Mervaala, Eero M.A
Format: Article
Language:English
Subjects:
Acetylcholine
Angiotensin Receptor Antagonists
Animals
Associated diseases and complications
Biological and medical sciences
Blood Pressure - drug effects
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Heart Rate - drug effects
Hypertension - complications
Hypertension - physiopathology
In Vitro Techniques
Medical sciences
Mesenteric Arteries - drug effects
Neprilysin - metabolism
Nitroprusside
Norepinephrine
Peptidyl-Dipeptidase A - metabolism
Rats
Rats, Wistar
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - metabolism
Sodium, Dietary - administration & dosage
Tetrazoles - pharmacology
Valine - analogs & derivatives
Valine - pharmacology
Valsartan
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Summary:Endothelial dysfunction is associated with hypertension, hypercholesterolemia, and heart failure. We tested the hypothesis that spontaneously diabetic Goto-Kakizaki (GK) rats, a model for type 2 diabetes, exhibit endothelial dysfunction. Rats also received a high-sodium diet (6% NaCl [wt/wt]) and chronic angiotensin type 1 (AT1) receptor blockade (10 mg/kg PO valsartan for 8 weeks). Compared with age-matched nondiabetic Wistar control rats, GK rats had higher blood glucose levels (9.3±0.5 versus 6.9±0.2 mmol/L for control rats), 2.7-fold higher serum insulin levels, and impaired glucose tolerance (all P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.37.2.433