A New Method for Removal of Albumin-Binding Uremic Toxins: Efficacy of an Albumin-Dialysate

: It is difficult for conventional hemodialysis to remove albumin‐binding uremic toxins (ABUTs) even though they are low molecular weight substances. We investigated the efficiency of albumin‐dialysate (AD) for removal of ABUT. Phenols and indoxyl sulfate were selected as ABUT. In vitro dialysis was...

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Bibliographic Details
Published in:Therapeutic apheresis 2001-02, Vol.5 (1), p.58-63
Main Authors: Abe, Takaya, Abe, Tomiya, Ageta, Shunrou, Kakuta, Takatosi, Suzuki, Nobuo, Hirata, Haruhisa, Shouno, Mineo, Saio, Hidetoshi, Akizawa, Tadao
Format: Article
Language:English
Subjects:
Albumin-binding uremic toxins
Albumin-dialysate
Continuous albumin purification system
Dialysis Solutions
Equipment Design
Humans
Membranes, Artificial
Renal Dialysis - instrumentation
Renal Dialysis - methods
Serum Albumin - metabolism
Toxins, Biological - blood
Uremia - blood
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Summary:: It is difficult for conventional hemodialysis to remove albumin‐binding uremic toxins (ABUTs) even though they are low molecular weight substances. We investigated the efficiency of albumin‐dialysate (AD) for removal of ABUT. Phenols and indoxyl sulfate were selected as ABUT. In vitro dialysis was performed for 2 h in the closed circuit with ABUT containing plasma as a test solution using conventional dialysate (CD) or AD. By the use of CD, the ABUT concentration in the test solution only was reduced by 20 to 30%. On the other hand, AD caused a marked reduction and an increase in test solution and dialysate concentration of ABUT, respectively. ABUT in AD could be adsorbed effectively by activated‐charcoal column; accordingly, the ABUT concentration in the test solution continued to decrease throughout the study period. These results suggest that AD could remove ABUT more efficiently than CD, and AD may be useful for reducing accumulated ABUT levels.
ISSN:1091-6660
1526-0968
DOI:10.1046/j.1526-0968.2001.005001058.x