Mutants in Glucose Metabolism

This review is about mutant studies in microbial glucose catabolism. It is largely restricted to the reactions of the glycolytic and pentose-phosphate pathways as far as pyruvate, principally for Escherichia coli and the yeast Saccharomyces cerevisiae . There is also mention of the same mutants in o...

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Bibliographic Details
Published in:Annual review of biochemistry 1986-01, Vol.55 (1), p.317-337
Main Author: Fraenkel, D G
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Biological and medical sciences
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Fructose-Bisphosphatase - genetics
Fructose-Bisphosphate Aldolase - genetics
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glucokinase - genetics
Glucose - metabolism
Glucose-6-Phosphate Isomerase - genetics
Glyceraldehyde 3-Phosphate - metabolism
Immunobiology
Miscellaneous
Mutation
Oxaloacetates - metabolism
Pentose Phosphate Pathway
Phosphoenolpyruvate - metabolism
Phosphofructokinase-1 - genetics
Pyruvate Kinase - genetics
Regulatory factors and their cellular receptors
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Triose-Phosphate Isomerase - genetics
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Summary:This review is about mutant studies in microbial glucose catabolism. It is largely restricted to the reactions of the glycolytic and pentose-phosphate pathways as far as pyruvate, principally for Escherichia coli and the yeast Saccharomyces cerevisiae . There is also mention of the same mutants in oxidative bacteria, where the reactions are employed in a somewhat different pattern. Emphasis is on contributions to understanding of metabolism, i.e. the degree to which mutants are informative about use and control of the reactions in vivo. Genetic studies are mentioned only in passing, but there is citation of cloning and sequencing because of their use in enzymology, particularly now that reverse genetics is allowing deliberate in vivo residue alteration.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.bi.55.070186.001533