Children with comorbid attention-deficit-hyperactivity disorder and tic disorder: Evidence for additive inhibitory deficits within the motor system

For children with attention‐deficit‐hyperactivity disorder (ADHD) or tic disorder (TD), we recently reported deficient inhibitory mechanisms within the motor system by using transcranial magnetic stimulation. These deficits—stated as reduced intracortical inhibition in ADHD and shortened cortical si...

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Bibliographic Details
Published in:Annals of neurology 2001-03, Vol.49 (3), p.393-396
Main Authors: Moll, Gunther H., Heinrich, Hartmut, Trott, Götz-Erik, Wirth, Sigrun, Bock, Nathalie, Rothenberger, Aribert
Format: Article
Language:English
Subjects:
Adolescent
Attention Deficit Disorder with Hyperactivity - complications
Attention Deficit Disorder with Hyperactivity - physiopathology
Biological and medical sciences
Child
Female
Humans
Magnetics
Male
Medical sciences
Motor Cortex - physiopathology
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Tic Disorders - complications
Tic Disorders - physiopathology
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Summary:For children with attention‐deficit‐hyperactivity disorder (ADHD) or tic disorder (TD), we recently reported deficient inhibitory mechanisms within the motor system by using transcranial magnetic stimulation. These deficits—stated as reduced intracortical inhibition in ADHD and shortened cortical silent period in TD—could be seen as neurophysiological correlates of motor hyperactivity and tics, respectively. To investigate neurophysiological aspects of comorbidity, we measured motor system excitability for the first time also in children with combined ADHD and TD. The findings of a reduced intracortical inhibition as well as a shortened cortical silent period in these comorbid children provide evidence for additive effects at the level of motor system excitability. Ann Neurol 2001;49:393–396
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.77