Exploiting molecular mimicry to broaden the immune response to carbohydrate antigens for vaccine development

Peptide mimetics of carbohydrates represent an alternative approach to induce anti-carbohydrate responses. Depending on their formulation, peptide mimetics can mediate T-independent or T-dependent responses. Multivalent peptide mimeotopes can induce high IgM/IgG ratios, as non-conjugated carbohydrat...

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Bibliographic Details
Published in:Vaccine 2001-03, Vol.19 (17), p.2361-2368
Main Authors: Cunto-Amesty, Gina, Luo, Ping, Monzavi-Karbassi, Behjatolah, Lees, Andrew, Kieber-Emmons, Thomas
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antibody Formation
Antigens - chemistry
Applied microbiology
B-Lymphocytes - immunology
Biological and medical sciences
Carbohydrate
Carbohydrates - chemistry
Carbohydrates - immunology
Cross Reactions
Female
Fundamental and applied biological sciences. Psychology
Immunization
immunoglobulin G1
Lewis Blood-Group System - chemistry
Lewis Blood-Group System - genetics
Lewis Y
Male
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Mice, Nude
Microbiology
Mimeotopes
Models, Biological
Molecular Mimicry
Molecular Sequence Data
Peptide
Peptides - genetics
Peptides - immunology
T-Lymphocytes - immunology
Vaccines
Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Conjugate - pharmacology
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Summary:Peptide mimetics of carbohydrates represent an alternative approach to induce anti-carbohydrate responses. Depending on their formulation, peptide mimetics can mediate T-independent or T-dependent responses. Multivalent peptide mimeotopes can induce high IgM/IgG ratios, as non-conjugated carbohydrates do. Here we observe that immunization with multivalent peptide mimeotope conjugated to BSA enhances carbohydrate reactive antibodies in Balb/c mice and xid mice, with IgG1 greater than IgG2a, in xid mice. These results suggest that mimeotope-conjugate formulations might augment carbohydrate-specific immune responses in immuno-compromised hosts.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(00)00527-2