Effects of rat ventral and dorsal hippocampus temporal inactivation on delayed alternation task

To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the c...

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Bibliographic Details
Published in:Brain research 2001-03, Vol.895 (1), p.273-276
Main Authors: Maruki, Kiyoyuki, Izaki, Yoshinori, Hori, Koji, Nomura, Masahiko, Yamauchi, Toshio
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Behavioral psychophysiology
Biological and medical sciences
Conditioning, Operant - drug effects
Conditioning, Operant - physiology
Dorsal hippocampus
Fundamental and applied biological sciences. Psychology
GABA Agonists - pharmacology
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - physiology
Male
Memory, Short-Term - drug effects
Memory, Short-Term - physiology
Muscimol - pharmacology
Neurons - cytology
Neurons - drug effects
Neurons - physiology
Operant-type delayed alternation
Perseveration
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Rats
Rats, Wistar
Temporal inactivation
Time Factors
Ventral hippocampus
Working memory
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Summary:To determine the involvement of the hippocampal regions in a operant-type delayed alternation task of short delay or long delay, microinjections of muscimol into the hippocampus were used for temporal inactivation during the behavioral test in each rat. Dorsal hippocampal inactivation impaired the correct ratio of long delay. Ventral hippocampal inactivation showed no changes in the correct ratio, however, it increased the tendency of perseveration in long delay. These findings suggest hippocampus has regional differentiation in delayed alternation task.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(01)02084-4