Intrauterine device and maternal copper metabolism during lactation

The effects of intrautuerine device (IUD) on maternal copper (Cu) metabolism during breastfeeding was studied in 95 volunteer mothers who chose to use non-hormonal contraceptive methods. They were divided into two groups that were inserted with the IUD-Cu 380A (n = 33), IUD-Cu 200B (n = 29), and a t...

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Bibliographic Details
Published in:Contraception (Stoneham) 2001, Vol.63 (1), p.37-39
Main Authors: Rodrigues da Cunha, A.C, Dorea, J.G, Cantuaria, A.A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Birth control
Breast milk
Cerulopasmin
Ceruloplasmin - analysis
Ceruloplasmin - metabolism
Copper
Copper - analysis
Copper - blood
Copper - metabolism
Endometrium
Endometrium - chemistry
Female
Gynecology. Andrology. Obstetrics
Humans
Intrauterine Devices, Copper - adverse effects
IUD
Lactation
Medical sciences
Milk, Human - chemistry
Milk, Human - metabolism
Other methods of contraception. Sterilization
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Summary:The effects of intrautuerine device (IUD) on maternal copper (Cu) metabolism during breastfeeding was studied in 95 volunteer mothers who chose to use non-hormonal contraceptive methods. They were divided into two groups that were inserted with the IUD-Cu 380A (n = 33), IUD-Cu 200B (n = 29), and a third group that did not use any IUDs served as control (n = 33). Endometrial biopsies, blood, and milk samples were collected before (at 10 weeks postpartum) and 6 weeks after insertion of device for the determination of metabolites associated with copper metabolism, namely, serum ceruloplasmin, and copper concentrations in breast milk and endometrium. Endometrial copper concentration increased in women using IUDs, but was statistically significant (p = 0.001) only in the IUD-Cu 380A group. The increase in endometrial copper concentration did not affect serum ceruloplasmin or milk copper concentrations.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(00)00191-8