Plasma levels of vascular endothelial growth factor and its soluble receptor (SFlt-1) in essential hypertension

In this study of 27 untreated patients with uncomplicated essential hypertension, we report on elevated plasma levels of vascular endothelial growth factor and its soluble receptor Flt-1 compared with healthy controls; these increased levels are reduced by the treatment of hypertension. This raises...

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Bibliographic Details
Published in:The American journal of cardiology 2001-03, Vol.87 (6), p.805-807
Main Authors: Belgore, Funmi M., Blann, Andrew D., Li-Saw-Hee, F.L., Beevers, D.Gareth, Lip, Gregory Y.H.
Format: Article
Language:English
Subjects:
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Cardiology
Cardiovascular system
Enalapril - therapeutic use
Endothelial Growth Factors - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypertension
Losartan - therapeutic use
Lymphokines - blood
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pilot Projects
Plasma
Prospective Studies
Proto-Oncogene Proteins - blood
Receptor Protein-Tyrosine Kinases - blood
Receptors, Growth Factor - blood
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factors
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Summary:In this study of 27 untreated patients with uncomplicated essential hypertension, we report on elevated plasma levels of vascular endothelial growth factor and its soluble receptor Flt-1 compared with healthy controls; these increased levels are reduced by the treatment of hypertension. This raises the possibility that abnormal angiogenesis may contribute to the pathogenesis of complications related to hypertension and merits exploration in larger studies.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01512-5