The Mechanical Behavior of Vascular Grafts: A Review

The development of intimal hyperplasia (IH) near the anastomosis of a vascular graft to artery is directly related to changes in the wall shear rate distribution. Mismatch in compliance and diameter at the end-to-end anastomosis of a compliant artery and rigid graft cause shear rate disturbances tha...

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Bibliographic Details
Published in:Journal of biomaterials applications 2001-01, Vol.15 (3), p.241-278
Main Authors: Salacinski, Henryk J., Goldner, Sean, Giudiceandrea, Alberto, Hamilton, George, Seifalian, Alexander M., Edwards, Alan, Carson, Robert J.
Format: Article
Language:English
Subjects:
Biocompatible Materials
Biological and medical sciences
Biomechanical Phenomena
Blood Vessel Prosthesis
Compliance
Medical sciences
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
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Summary:The development of intimal hyperplasia (IH) near the anastomosis of a vascular graft to artery is directly related to changes in the wall shear rate distribution. Mismatch in compliance and diameter at the end-to-end anastomosis of a compliant artery and rigid graft cause shear rate disturbances that may induce intimal hyperplasia and ultimately graft failure. The principal strategy being developed to prevent IH is based on the design and fabrication of compliant synthetic or innovative tissue-engineered grafts with viscoelastic properties that mirror those of the human artery. The goal of this review is to discuss how mechanical properties including compliance mismatch, diameter mismatch, Young’s modulus and impedance phase angle affect graft failure due to intimal hyperplasia.
ISSN:0885-3282
1530-8022
DOI:10.1106/NA5T-J57A-JTDD-FD04