Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia Pneumoniae infection in the development of coronary atherosclerosis

Studies have suggested that the prevalence of antibodies against heat-shock proteins (HSPs), Chlamydia pneumoniae (CPN), and cytomegalovirus (CMV) is associated with coronary artery disease (CAD), but the independent or joint effects of human (h) HSP60 antibodies and these pathogens in patients have...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-03, Vol.103 (11), p.1503-1508
Main Authors: BURIAN, Katalin, KIS, Zoltan, FUST, George, GONCZOL, Eva, VIROK, Dezso, ENDRESZ, Valeria, PROHASZKA, Zoltan, DUBA, Jeno, BERENCSI, Klara, BODA, Krisztina, HORVATH, Laura, ROMICS, Laszlo
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies - pharmacology
Biological and medical sciences
Cardiology. Vascular system
Chaperonin 60 - immunology
Chlamydia Infections - complications
Chlamydia Infections - immunology
Chlamydophila pneumoniae
Coronary Artery Disease - etiology
Coronary Artery Disease - microbiology
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Risk Factors
Smoking - immunology
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Summary:Studies have suggested that the prevalence of antibodies against heat-shock proteins (HSPs), Chlamydia pneumoniae (CPN), and cytomegalovirus (CMV) is associated with coronary artery disease (CAD), but the independent or joint effects of human (h) HSP60 antibodies and these pathogens in patients have not been fully elucidated. A total of 405 subjects (276 patients with CAD and 129 control individuals) were tested for serum antibodies to hHSP60, CPN, and CMV immediate-early-1 (IE1) antigens. Patients were also assessed for serum cholesterol, triglyceride levels, and smoking habit. Significantly elevated levels of antibodies to hHSP60 and CPN but not to CMV-IE1 antigens were documented in CAD patients. Multiple logistic regression analysis and subanalyses of selected subjects showed that these associations were independent of age, sex, smoking, and serum lipid levels. Antibodies to hHSP60 and CPN did not correlate quantitatively; however, the relative risk of disease development was substantially increased in subjects with high antibody levels to both hHSP60 and CPN:, reaching an odds ratio of 82.0 (95% CI 10.6 to 625.0). High levels of antibodies to hHSP60 and CPN: are independent risk factors for coronary atherosclerosis, but their simultaneous presence substantially increases the risk for disease development.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.103.11.1503