The Treatment of the Restless Legs Syndrome with Clonazepam: A Prospective Controlled Study

The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients. Following a drug-free period, 3 patients received clonazepam for 4 weeks followed by placebo for 4 weeks thereafter and 3 patients received the same medication and for the same length of time but in reverse...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 1986-08, Vol.13 (3), p.245-247
Main Authors: Boghen, Dan, Lamothe, Lise, Elie, Robert, Godbout, Roger, Montplaisir, Jacques
Format: Article
Language:English
Subjects:
Adult
Benzodiazepinones - therapeutic use
Biological and medical sciences
Clinical Trials as Topic
Clonazepam - therapeutic use
Female
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Neuropharmacology
Original Articles
Pharmacology. Drug treatments
Prospective Studies
Restless Legs Syndrome - drug therapy
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Summary:The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients. Following a drug-free period, 3 patients received clonazepam for 4 weeks followed by placebo for 4 weeks thereafter and 3 patients received the same medication and for the same length of time but in reverse order. The effectiveness of the medication was evaluated by means of a self-rating system in which patients assigned a score daily to the degree of discomfort experienced in the previous 24 hours. Three patients improved on clonazepam but 2 of these also improved on placebo. Clonazepam was not shown to be significantly more effective than placebo in the treatment of RLS.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100036350