A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple's disease

• Published in: Infection 2001-01, Vol.29 (1), p.44-47
• Main Authors: GEISSDÖRFER, W, WITTMANN, I, SEITZ, G, CESNJEVAR, R, ROLLINGHOFF, M, SCHOERNER, C, BOGDAN, C
• Format: Article
• Language: English
• Subjects: Actinobacteria - genetics; Actinobacteria - isolation & purification; Actinomycetales Infections - diagnosis; Actinomycetales Infections - microbiology; Aged; Aortic Valve - microbiology; Aortic Valve Insufficiency - complications; Aortic Valve Insufficiency - microbiology; Bacterial diseases; Bacterial endocarditis, myocarditis and pericarditis. Bacterial diseases of the aorta, limb vessels and lymphatic vessels; Biological and medical sciences; DNA, Ribosomal - analysis; Endocarditis, Bacterial - diagnosis; Endocarditis, Bacterial - microbiology; Gene Amplification; Giardiasis - complications; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Polymerase Chain Reaction; Tropheryma whippelii; Whipple Disease - diagnosis; Whipple Disease - microbiology
• ISSN: 0300-8126; 1439-0973
• DOI: 10.1007/s15010-001-0135-9

A case of endocarditis caused by Tropheryma whippelii is reported. The 69-year-old patient was diagnosed as suffering from severe aortic regurgitation requiring aortic valve replacement, but showed no other symptoms of Whipple's disease. T. whippelii was detected in the explanted aortic valve by broad-range PCR amplification of the 16S rDNA and subsequent sequence analysis of the product. The etiologic agent was classified as a type 2A sequence variant based on the 16S-23S intergenic spacer and the 23S rDNA (domain III) sequences. The histological examination of the aortic valve was compatible with Whipple's disease. A duodenal biopsy revealed an infection with Giardia lamblia, but T. whippelii and histological signs of Whipple's disease were not detectable.