Treatment of severe thrombocytopenia in alloimmunized, transfusion-refractory patients

A significant proportion of patients with hematologic malignancies who are exposed to multiple transfusions will develop alloantibodies to platelet human leukocyte antigens (HLA), resulting in poor responses to subsequent platelet transfusions. Transfusion of HLA-identical platelets is an effective...

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Bibliographic Details
Published in:Military medicine 2001-03, Vol.166 (3), p.269-274
Main Authors: ORNSTEIN, Deborah L, MORTARA, Kevin L, SMITH, Michael B, RIRIE, David W, SHAUGHNESSY, Paul J, BICKFORD, David J, KISSACK, Brenda L
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Group Incompatibility - complications
Blood Group Incompatibility - diagnosis
Blood Group Incompatibility - immunology
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Clinical Protocols
Female
Histocompatibility Testing
HLA Antigens - immunology
Humans
Isoantibodies - blood
Isoantibodies - immunology
Leukemia, Myeloid - therapy
Medical sciences
Military Medicine - methods
Platelet Transfusion - methods
Practice Guidelines as Topic
Thrombocytopenia - diagnosis
Thrombocytopenia - etiology
Thrombocytopenia - therapy
Transfusion Reaction
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
United States
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Description
Summary:A significant proportion of patients with hematologic malignancies who are exposed to multiple transfusions will develop alloantibodies to platelet human leukocyte antigens (HLA), resulting in poor responses to subsequent platelet transfusions. Transfusion of HLA-identical platelets is an effective method of platelet support in these patients, but perfectly HLA-matched platelets are often not available. In this paper, we review the recent literature on platelet transfusion support in alloimmunized individuals and illustrate alternative management strategies with cases from our own practice.
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/166.3.269