Synthesis of a 3,4,5-Trimethoxybenzoyl Ester Analogue of Epigallocatechin-3-gallate (EGCG):  A Potential Route to the Natural Product Green Tea Catechin, EGCG

The synthesis of a trimethoxybenzoyl ester (D-ring) analogue of epigallocatechin-3-gallate (EGCG) is described. The versatile synthesis route can be used to synthesize A, B, and D ring analogues of EGCG and involves a key cyclization of the chalcone to the 3-flavene. This synthesis provides a possib...

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Published in:Organic letters 2001-03, Vol.3 (6), p.843-846
Main Author: Zaveri, Nurulain T
Format: Article
Language:English
Subjects:
Catechin - analogs & derivatives
Catechin - chemical synthesis
Catechin - chemistry
Esters - chemical synthesis
Indicators and Reagents
Models, Molecular
Molecular Conformation
Molecular Structure
Structure-Activity Relationship
Tea
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description The synthesis of a trimethoxybenzoyl ester (D-ring) analogue of epigallocatechin-3-gallate (EGCG) is described. The versatile synthesis route can be used to synthesize A, B, and D ring analogues of EGCG and involves a key cyclization of the chalcone to the 3-flavene. This synthesis provides a possible route to the polyphenolic green tea natural product EGCG.
doi_str_mv 10.1021/ol007000o
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Catechin - analogs & derivatives
Catechin - chemical synthesis
Catechin - chemistry
Esters - chemical synthesis
Indicators and Reagents
Models, Molecular
Molecular Conformation
Molecular Structure
Structure-Activity Relationship
Tea
title Synthesis of a 3,4,5-Trimethoxybenzoyl Ester Analogue of Epigallocatechin-3-gallate (EGCG):  A Potential Route to the Natural Product Green Tea Catechin, EGCG
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