Candida dubliniensis at a Cancer Center

Candida dubliniensis, a germ tube-positive yeast first described and identified as a cause of oral candidiasis in patients with acquired immunodeficiency syndrome in Europe in 1995, has an expanding clinical and geographic distribution that appears to be similar to that of the other germ tube-positi...

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Bibliographic Details
Published in:Clinical infectious diseases 2001-04, Vol.32 (7), p.1034-1038
Main Authors: Sebti, Abdelghani, Kiehn, Timothy E., Perlin, David, Chaturvedi, Vishnu, Wong, May, Doney, Andrea, Park, Steven, Sepkowitz, Kent A.
Format: Article
Language:English
Subjects:
5-Fluorocytosine
Adult
Aged
Aged, 80 and over
AIDS
Antifungal Agents - pharmacology
Antifungals
Biological and medical sciences
Blood
Cancer
Candida
Candida - classification
Candida - drug effects
Candida - genetics
Candida - isolation & purification
Candida dubliniensis
Candidiasis - microbiology
Female
flucytosine
Follow-Up Studies
Fungal infections
Genotype
Human immunodeficiency virus
Human mycoses
Humans
Infections
Infectious diseases
Major Articles
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Miscellaneous mycoses
Mycoses
Neoplasms - complications
Nervous system diseases
Phenotype
Sputum
Yeasts
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Summary:Candida dubliniensis, a germ tube-positive yeast first described and identified as a cause of oral candidiasis in patients with acquired immunodeficiency syndrome in Europe in 1995, has an expanding clinical and geographic distribution that appears to be similar to that of the other germ tube-positive yeast, Candida albicans. This study determined the frequency, clinical spectrum, drug susceptibility profile, and suitable methods for identification of this emerging pathogen at a cancer center in 1998 and 1999. Twenty-two isolates were recovered from 16 patients with solid-organ or hematologic malignancies or acquired immunodeficiency syndrome. Two patients with cancer had invasive infection, and 14 were colonized with fungus or had superficial fungal infection. All isolates produced germ tubes and chlamydospores at 37°C, did not grow at 45°C, and gave negative reactions with d-xylose and α-methyl-d-glucoside in the API 20 C AUX and ID 32 C yeast identification systems. Phenotypic identification was confirmed by molecular beacon probe technology. All isolates were susceptible to the antifungal drugs amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, and ketoconazole.
ISSN:1058-4838
1537-6591
DOI:10.1086/319599