Changes occurring in the epithelium covering the bronchus-associated lymphoid tissue of rats after intratracheal challenge with horseradish peroxidase

Changes occurring in the epithelium covering bronchus-associated lymphoid tissue (BALT) in the rat after several intratracheal administrations of horseradish peroxidase (HRP) were studied using morphological and ultrastructural methods. The epithelium is invaded by W3/25-positive (T-helper) lymphocy...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 1986-01, Vol.245 (2), p.439-444
Main Authors: VAN DER BRUGGE-GAMELKOORN, G. J, VAN DE ENDE, M, SMINIA, T
Format: Article
Language:English
Subjects:
Animals
Antigens
Biological and medical sciences
Bronchi - cytology
Bronchi - immunology
Bronchi - ultrastructure
Epithelial Cells
Epithelium - immunology
Epithelium - ultrastructure
Fundamental and applied biological sciences. Psychology
Histocompatibility Antigens Class II - analysis
Horseradish Peroxidase
Immunoenzyme Techniques
Immunoglobulin A - analysis
Lymphocytes - cytology
Lymphocytes - immunology
Lymphocytes - ultrastructure
Male
Microscopy, Electron
Peroxidases
Rats
Rats, Inbred Strains
Vertebrates: blood, hematopoietic organs, reticuloendothelial system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Changes occurring in the epithelium covering bronchus-associated lymphoid tissue (BALT) in the rat after several intratracheal administrations of horseradish peroxidase (HRP) were studied using morphological and ultrastructural methods. The epithelium is invaded by W3/25-positive (T-helper) lymphocytes, the BALT epithelial cells become Ia-positive and develop microvilli; there is an apparent loss of cilia. The number of non-ciliated cells in stimulated BALT increases. The non-ciliated cells can be subdivided into two cell types, one with electron-dense cytoplasm and cytoplasmic granules and the other without granules. The electron-density of the latter cell type is intermediate between that of the ciliated cells and that of the granule-containing non-ciliated cells. The granule-containing cell types may be responsible for the uptake of antigens, while the other non-ciliated cell may be involved in the production of the secretory component and the passage of secretory IgA.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00213952