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Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses

A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserv...

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Published in:	Molecular biology and evolution 2001-04, Vol.18 (4), p.577-584
Main Authors:	Ragg, H, Lokot, T, Kamp, P B, Atchley, W R, Dress, A
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence - genetics Animals Exons - genetics Humans Introns - genetics Models, Statistical Multigene Family Phylogeny Serine Proteinase Inhibitors - classification Serine Proteinase Inhibitors - genetics serpin Serpins - classification Serpins - genetics Vertebrata
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creator	Ragg, H Lokot, T Kamp, P B Atchley, W R Dress, A
description	A combination of three independent biological features, genomic organization, diagnostic amino acid sites, and rare indels, was used to elucidate the phylogeny of the vertebrate serpin (serine protease inhibitor) superfamily. A strong correlation between serpin gene families displaying (1) a conserved exon-intron pattern and (2) family-specific combinations of amino acid residues at specific sites suggests that present-day vertebrates encompass six serpin gene families which evolved from primordial genes by massive intron insertion before or during early vertebrate radiation. Introns placed at homologous positions in the gene sequences in combination with diagnostic sequence characters may also constitute a reliable kinship indicator for other protein superfamilies.
doi_str_mv	10.1093/oxfordjournals.molbev.a003838
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source	Oxford Journals Open Access Collection; Free Full-Text Journals in Chemistry
subjects	Amino Acid Sequence - genetics Animals Exons - genetics Humans Introns - genetics Models, Statistical Multigene Family Phylogeny Serine Proteinase Inhibitors - classification Serine Proteinase Inhibitors - genetics serpin Serpins - classification Serpins - genetics Vertebrata
title	Vertebrate serpins: construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses
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