Ca(2+)/CaM-dependent kinases: from activation to function

Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunction...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2001, Vol.41, p.471-505
Main Authors: Hook, S S, Means, A R
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Calcium Signaling - physiology
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Calcium-Calmodulin-Dependent Protein Kinases - physiology
Enzyme Activation - physiology
Humans
Molecular Sequence Data
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Summary:Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our review focuses on this class of CaM kinases to illustrate the structural and biochemical basis for Ca(2+)/CaM interaction with and regulation of its target enzymes. Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev.pharmtox.41.1.471