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Ca(2+)/CaM-dependent kinases: from activation to function
Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunction...
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Published in: | Annual review of pharmacology and toxicology 2001, Vol.41, p.471-505 |
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container_title | Annual review of pharmacology and toxicology |
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creator | Hook, S S Means, A R |
description | Calmodulin (CaM) is an essential protein that serves as a ubiquitous intracellular receptor for Ca(2+). The Ca(2+)/CaM complex initiates a plethora of signaling cascades that culminate in alteration of cellular functions. Among the many Ca(2+)/CaM-binding proteins to be discovered, the multifunctional protein kinases CaMKI, II, and IV play pivotal roles. Our review focuses on this class of CaM kinases to illustrate the structural and biochemical basis for Ca(2+)/CaM interaction with and regulation of its target enzymes. Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms. |
doi_str_mv | 10.1146/annurev.pharmtox.41.1.471 |
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issn | 0362-1642 1545-4304 |
language | eng |
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source | Annual Reviews |
subjects | Amino Acid Sequence Animals Calcium Signaling - physiology Calcium-Calmodulin-Dependent Protein Kinases - metabolism Calcium-Calmodulin-Dependent Protein Kinases - physiology Enzyme Activation - physiology Humans Molecular Sequence Data |
title | Ca(2+)/CaM-dependent kinases: from activation to function |
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