Platelet glass bead retention predicts bleeding after cardiac surgery

To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Prospective, observational study. Large, tertiary care, academic medical center. Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Whole...

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2001-02, Vol.15 (1), p.49-54
Main Authors: ERETH, Mark H, NUTTALL, Gregory A, ERICSON, Daniel G, COONEY, William P, FISHER, Brent R, OLIVER, William C, SCHAFF, Hartzell V, FASS, David N
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Anticoagulants - therapeutic use
Biological and medical sciences
Blood Platelets - physiology
Cardiac Surgical Procedures - adverse effects
Cardiopulmonary Bypass
Female
Heparin - therapeutic use
Humans
Male
Medical sciences
Middle Aged
Partial Thromboplastin Time
Platelet Count
Platelet Function Tests - methods
Postoperative Complications - blood
Postoperative Hemorrhage - blood
Predictive Value of Tests
Prothrombin Time
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
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Summary:To determine if the platelet glass bead retention assay can predict bleeding after cardiac surgery. Prospective, observational study. Large, tertiary care, academic medical center. Forty-three adult patients scheduled to undergo elective cardiac surgery employing cardiopulmonary bypass (CPB). Whole blood samples were observed for platelet count, prothrombin time, and platelet (glass bead) retention assay. The platelet retention and prothrombin times were independent univariant and multivariant predictors of bleeding after CPB (r = 0.554, p = 0.0002 and r = 0.655, p = 0.00001). The platelet glass bead retention assay measures dynamic platelet function and is sensitive to the CPB-induced adhesion and aggregation defect and correlates with postoperative blood loss. Modification of this platelet function assay used with the prothrombin time may provide a simple and effective diagnostic approach to bleeding after CPB.
ISSN:1053-0770
1532-8422
DOI:10.1053/jcan.2001.20274