Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains

• Published in: Journal of antimicrobial chemotherapy 2001-04, Vol.47 (4), p.479-482
• Main Authors: Rodríguez-Hernández, María-Jesús, Cuberos, Lucila, Pichardo, Cristina, Caballero, Francisco J., Moreno, Ignacio, Jiménez-Mejías, M. Enrique, García-Curiel, Andrés, Pachón, Jerónimo
• Format: Article
• Language: English
• Subjects: Acinetobacter - drug effects; Acinetobacter Infections - blood; Acinetobacter Infections - drug therapy; Acinetobacter Infections - microbiology; Animals; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Disease Models, Animal; Endocarditis - blood; Endocarditis - drug therapy; Endocarditis - microbiology; Heart Valves - drug effects; Heart Valves - microbiology; Imipenem - pharmacokinetics; Imipenem - pharmacology; Imipenem - therapeutic use; Lung - drug effects; Lung - microbiology; Medical sciences; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pneumonia - blood; Pneumonia - drug therapy; Pneumonia - microbiology; Rabbits; Sulbactam - pharmacokinetics; Sulbactam - pharmacology; Sulbactam - therapeutic use; Survival Rate; Time Factors
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/47.4.479

Sulbactam and imipenem were compared in an experimental pneumonia model in immunocompetent mice, using a susceptible strain of Acinetobacter baumannii, and in an experimental endocarditis model in rabbits, using an intermediately susceptible strain. In the former, sulbactam was as efficacious as imipenem in terms of survival, sterility of lungs and in the bacterial clearance from lungs and blood, provided that the t > MIC for sulbactam (1.84 h) was similar to that for imipenem (2.01 h). In the endocarditis model, imipenem (t > MIC, 2.12 h) was more efficacious than sulbactam (t > MIC, 1.17 h) in bacterial clearance from vegetations. These results show the efficacy of sulbactam in infections caused by susceptible strains of A. baumannii, with an MIC up to 4 mg/L, provided that doses reach a t > MIC similar to that of imipenem. The activity of sulbactam was time dependent.