Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint

• Published in: Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-02, Vol.68 (2), p.229-233
• Main Authors: Ribeiro-de-Oliveira, Antonio, Guerra, Rachel Menezes, Fóscolo, Rodrigo Bastos, Marubayashi, Umeko, Reis, Adelina Martha dos, Coimbra, Cândido Celso
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Bromocriptine; Bromocriptine - pharmacology; Catecholaminergic system; Dopamine Agonists - pharmacology; Fundamental and applied biological sciences. Psychology; Hyperglycemia; Hyperglycemia - blood; Insulin; Insulin - blood; Male; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Personality. Affectivity; Pharmacology. Drug treatments; Prolactin; Prolactin - blood; Prolactin - drug effects; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rats, Wistar; Restraint, Physical; Restraint-stress; Stress; Stress, Physiological - blood
• ISSN: 0091-3057; 1873-5177
• DOI: 10.1016/S0091-3057(00)00453-6

The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D 2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the plasma prolactin of vehicle-treated (VEH) rats increased rapidly, reaching a peak at 10 min (57.9±8.1 ng/ml, P