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Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint
The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D 2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the...
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| Published in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-02, Vol.68 (2), p.229-233 |
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| cited_by | cdi_FETCH-LOGICAL-c486t-ae30ec791469d2a387f50c90e4110cfdae1599e6399468a6045d87c5973b08d73 |
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| cites | cdi_FETCH-LOGICAL-c486t-ae30ec791469d2a387f50c90e4110cfdae1599e6399468a6045d87c5973b08d73 |
| container_end_page | 233 |
| container_issue | 2 |
| container_start_page | 229 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 68 |
| creator | Ribeiro-de-Oliveira, Antonio Guerra, Rachel Menezes Fóscolo, Rodrigo Bastos Marubayashi, Umeko Reis, Adelina Martha dos Coimbra, Cândido Celso |
| description | The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D
2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the plasma prolactin of vehicle-treated (VEH) rats increased rapidly, reaching a peak at 10 min (57.9±8.1 ng/ml,
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| doi_str_mv | 10.1016/S0091-3057(00)00453-6 |
| format | article |
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2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the plasma prolactin of vehicle-treated (VEH) rats increased rapidly, reaching a peak at 10 min (57.9±8.1 ng/ml,
P<.01). In contrast, restraint failed to induce any significant change in the plasma prolactin levels of bromocriptine-treated (BR) rats. The hyperglycemic response to immobilization was 97% higher (
P<.05) in BR rats than in VEH rats. Our data demonstrate that prolactin secretion and hyperglycemia in response to restraint can be dissociated by chronic treatment with BR, which also increased the hyperglycemic response to immobilization probably due to central D
2 dopaminergic activity.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(00)00453-6</identifier><identifier>PMID: 11267627</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Bromocriptine ; Bromocriptine - pharmacology ; Catecholaminergic system ; Dopamine Agonists - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hyperglycemia ; Hyperglycemia - blood ; Insulin ; Insulin - blood ; Male ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Personality. Affectivity ; Pharmacology. Drug treatments ; Prolactin ; Prolactin - blood ; Prolactin - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Restraint, Physical ; Restraint-stress ; Stress ; Stress, Physiological - blood</subject><ispartof>Pharmacology, biochemistry and behavior, 2001-02, Vol.68 (2), p.229-233</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-ae30ec791469d2a387f50c90e4110cfdae1599e6399468a6045d87c5973b08d73</citedby><cites>FETCH-LOGICAL-c486t-ae30ec791469d2a387f50c90e4110cfdae1599e6399468a6045d87c5973b08d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=942195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11267627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro-de-Oliveira, Antonio</creatorcontrib><creatorcontrib>Guerra, Rachel Menezes</creatorcontrib><creatorcontrib>Fóscolo, Rodrigo Bastos</creatorcontrib><creatorcontrib>Marubayashi, Umeko</creatorcontrib><creatorcontrib>Reis, Adelina Martha dos</creatorcontrib><creatorcontrib>Coimbra, Cândido Celso</creatorcontrib><title>Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D
2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the plasma prolactin of vehicle-treated (VEH) rats increased rapidly, reaching a peak at 10 min (57.9±8.1 ng/ml,
P<.01). In contrast, restraint failed to induce any significant change in the plasma prolactin levels of bromocriptine-treated (BR) rats. The hyperglycemic response to immobilization was 97% higher (
P<.05) in BR rats than in VEH rats. Our data demonstrate that prolactin secretion and hyperglycemia in response to restraint can be dissociated by chronic treatment with BR, which also increased the hyperglycemic response to immobilization probably due to central D
2 dopaminergic activity.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Bromocriptine</subject><subject>Bromocriptine - pharmacology</subject><subject>Catecholaminergic system</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - blood</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Personality. Affectivity</subject><subject>Pharmacology. Drug treatments</subject><subject>Prolactin</subject><subject>Prolactin - blood</subject><subject>Prolactin - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical</subject><subject>Restraint-stress</subject><subject>Stress</subject><subject>Stress, Physiological - blood</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkU1P3DAQhq0KVJaPn9AqEhKCQ2CcxF8nRFELSEg9tBVHy9iT1lVip3YWaf99vewKjnuaOTwz7_gxIZ8oXFKg_OoHgKJ1C0ycA1wAdKyt-QeyoFK0NaNC7JHFG3JADnP-C4VquPhIDigtlTdiQZ6-pDhGm_w0-4C1D25p0VXO5xytN7OPoYp99Wc1Yfo9rCyO3lQmuGpKcTC2DFUJ8xRDxmqO635Oxof5mOz3Zsh4sq1H5Ne3rz9v7-vH73cPtzePte0kn2uDLaAVinZcuca0UvQMrALsKAXbO4OUKYW8Varj0vDyTCeFZUq0zyCdaI_I2WZvueffsqTr0WeLw2ACxmXWgislWcN3glRIpphUBWQb0KaYc8JeT8mPJq00Bb1Wr1_V67VXDaBf1et1wOdtwPJ5RPc-tXVdgNMtYLI1Q59MsD6_caprqGKFut5QWKy9eEw6W4-hfIpPaGftot9xyH-QKqBK</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Ribeiro-de-Oliveira, Antonio</creator><creator>Guerra, Rachel Menezes</creator><creator>Fóscolo, Rodrigo Bastos</creator><creator>Marubayashi, Umeko</creator><creator>Reis, Adelina Martha dos</creator><creator>Coimbra, Cândido Celso</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint</title><author>Ribeiro-de-Oliveira, Antonio ; Guerra, Rachel Menezes ; Fóscolo, Rodrigo Bastos ; Marubayashi, Umeko ; Reis, Adelina Martha dos ; Coimbra, Cândido Celso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-ae30ec791469d2a387f50c90e4110cfdae1599e6399468a6045d87c5973b08d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Bromocriptine</topic><topic>Bromocriptine - pharmacology</topic><topic>Catecholaminergic system</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - blood</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Personality. Affectivity</topic><topic>Pharmacology. Drug treatments</topic><topic>Prolactin</topic><topic>Prolactin - blood</topic><topic>Prolactin - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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P<.01). In contrast, restraint failed to induce any significant change in the plasma prolactin levels of bromocriptine-treated (BR) rats. The hyperglycemic response to immobilization was 97% higher (
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| ispartof | Pharmacology, biochemistry and behavior, 2001-02, Vol.68 (2), p.229-233 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Bromocriptine Bromocriptine - pharmacology Catecholaminergic system Dopamine Agonists - pharmacology Fundamental and applied biological sciences. Psychology Hyperglycemia Hyperglycemia - blood Insulin Insulin - blood Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Personality. Affectivity Pharmacology. Drug treatments Prolactin Prolactin - blood Prolactin - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Restraint, Physical Restraint-stress Stress Stress, Physiological - blood |
| title | Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint |
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