An Experimental Study Evaluating the Effect of Mitomycin C on the Prevention of Postoperative Intraabdominal Adhesions

Background. Fibroblast proliferation is one of the well-known mechanisms for postoperative intraabdominal adhesion formation. Inhibition of fibroblast proliferation is an attractive field of investigation in the prevention of adhesions. Mitomycin C (MMC) is a cytotoxic agent that alkylates and cross...

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Published in:The Journal of surgical research 2001-04, Vol.96 (2), p.163-166
Main Authors: Çubukçu, Anıl, Alponat, Ahmet, Gönüllü, Neşet Nuri, Özkan, Suat, Erçin, Cengiz
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Digestive system
Drug Evaluation
Female
Intestinal Diseases - pathology
Intestinal Diseases - prevention & control
intraabdominal adhesions
Medical sciences
Mitomycin - pharmacology
mitomycin C
Nucleic Acid Synthesis Inhibitors - pharmacology
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
prevention
Rats
Rats, Wistar
Tissue Adhesions - pathology
Tissue Adhesions - prevention & control
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Summary:Background. Fibroblast proliferation is one of the well-known mechanisms for postoperative intraabdominal adhesion formation. Inhibition of fibroblast proliferation is an attractive field of investigation in the prevention of adhesions. Mitomycin C (MMC) is a cytotoxic agent that alkylates and crosslinks DNA and also inhibits fibroblast proliferation up to a few weeks. We aimed to determine the effect of MMC on the prevention of adhesions. Materials and methods. Generation of adhesions in rats by brushing a 1-cm2 area of the cecum and the peritoneum on the right side of the abdominal wall was followed by intraperitoneal administration of saline, 1 mg/kg MMC, and 0.5 mg/kg MMC in saline. After 45 days, formation of adhesions was graded. Results. The average adhesion scores of the control, and MMC (1 mg/kg), MMC (0.5 mg/kg) groups were 3.2 ± 0.7, 0.8 ± 0.6, and 0.7 ± 0.8, respectively. Adhesion scores of the two MMC-treated groups were significantly lower than that of the control group (P < 0.001). There was no difference between the two MMC groups (P > 0.05). No side effect of MMC was observed. Conclusion. MMC was found to be very effective in the prevention of postoperative intraabdominal adhesions.
ISSN:0022-4804
1095-8673
DOI:10.1006/jsre.2000.6059