Cell-mediated immune reactions against B cells and defect of suppressor cell activity in type 1 (insulin-dependent) diabetes mellitus

A cytotoxic effect of peripheral blood mononuclear cells from 22 out of 23 newly diagnosed Type 1 (insulin-dependent) diabetic patients against B cells of isolated rat islets was demonstrated. The addition of peripheral blood mononuclear cells from healthy subjects reduced the cytotoxic effect in 9...

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia 1986-07, Vol.29 (7), p.421-425
Main Authors: LOHMANN, D, KRUG, J, LAMPETER, E. F, BIERWOLF, B, VERLOHREN, H.-J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Cytotoxicity, Immunologic
Diabetes Mellitus, Type 1 - immunology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Histocompatibility Antigens Class II - analysis
HLA-DR Antigens
Humans
Immunity, Cellular
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - immunology
Lymphocytes - immunology
Male
Medical sciences
T-Lymphocytes, Regulatory - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A cytotoxic effect of peripheral blood mononuclear cells from 22 out of 23 newly diagnosed Type 1 (insulin-dependent) diabetic patients against B cells of isolated rat islets was demonstrated. The addition of peripheral blood mononuclear cells from healthy subjects reduced the cytotoxic effect in 9 out of 10 patients. The addition of peripheral blood mononuclear cells from other diabetic patients was without significant effect in 14 out of 16 cases. The results indicate functional abnormalities of peripheral blood mononuclear cells in newly diagnosed Type 1 diabetes. Beside cytotoxic effects against B cells, a defect in the suppressor function seems to exist. The activation of T-lymphocytes might be a consequence of such a defect.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00506532