Apolipoprotein E polymorphism and serum lipoprotein(a) concentrations in a Korean male population

The purpose of this study was to investigate the effect of apolipoprotein E polymorphism on lipoprotein(a) metabolism by comparing serum lipoprotein(a) concentration with apolipoprotein E genotype in a Korean male population whose high molecular weight (HMW) lipoprotein(a) frequency was 95-98%. Seru...

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Bibliographic Details
Published in:Annals of clinical biochemistry 2001-03, Vol.38 (2), p.129-134
Main Authors: CHUN, Sail, MIN, Won-Ki, KIM, Jong-Won, PARK, Hyosoon, JANG, Seongsoo, YANG, Sung-Eun, KIM, Jin Q
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Apolipoproteins E - blood
Apolipoproteins E - genetics
Biological and medical sciences
Cholesterol Esters - blood
Cholesterol, HDL - blood
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genotype
Humans
Korea
Lipoprotein(a) - blood
Lipoprotein(a) - genetics
Lipoproteins, myelin
Male
Middle Aged
Molecular Weight
Polymerase Chain Reaction
Polymorphism, Genetic
Proteins
Triglycerides - blood
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Summary:The purpose of this study was to investigate the effect of apolipoprotein E polymorphism on lipoprotein(a) metabolism by comparing serum lipoprotein(a) concentration with apolipoprotein E genotype in a Korean male population whose high molecular weight (HMW) lipoprotein(a) frequency was 95-98%. Serum lipoprotein(a), total cholesterol, triglyceride and high-density lipoprotein-cholesterol concentrations were measured and the apolipoprotein E genotype determined in 1189 healthy Korean males. The medians of serum lipoprotein(a) concentration in the apoE 2/3 group (0.105g/L) and the apoE 3/4 group (0·116g/L) were significantly lower than that in the apoE 3/3 group (0·155g/L; P
ISSN:0004-5632
1758-1001
DOI:10.1258/0004563011900434