The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game

The DAP (Death Associated Protein) kinase family is a novel subfamily of pro‐apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is lar...

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Bibliographic Details
Published in:BioEssays 2001-04, Vol.23 (4), p.352-358
Main Authors: Kögel, Donat, Prehn, Jochen H.M., Scheidtmann, Karl Heinz
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Apoptosis
Apoptosis Regulatory Proteins
Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Calcium-Calmodulin-Dependent Protein Kinases - physiology
Death-Associated Protein Kinases
Enzyme Activation
Humans
Molecular Sequence Data
Protein-Serine-Threonine Kinases - metabolism
Protein-Serine-Threonine Kinases - physiology
Signal Transduction - physiology
Subcellular Fractions
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Summary:The DAP (Death Associated Protein) kinase family is a novel subfamily of pro‐apoptotic serine/threonine kinases. All five DAP kinase family members identified to date are ubiquitously expressed in various tissues and are capable of inducing apoptosis. The sequence homology of the five kinases is largely restricted to the N‐terminal kinase domain. In contrast, the adjacent C‐terminal regions are very diverse and link individual family members to specific signal transduction pathways. There is increasing evidence that DAP kinase family members are involved in both extrinsic and intrinsic pathways of apoptosis and may play a role in tumor progression. This review will focus on structural composition and subcellular localization of DAP kinase family members and on signal transduction pathways leading to their activation. Potential mechanisms of DAP kinase family‐mediated apoptosis will be discussed. BioEssays 23:352–358, 2001. © 2001 John Wiley & Sons, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.1050