Effect of Ibuprofen on Gross Pathology, Bacterial Count, and Levels of Prostaglandin E2 in Experimental Staphylococcal Osteomyelitis

Infections with Staphylococcus aureus were induced in rat tibiae without sclerosing agents. Animals received ibuprofen or 0.9% NaCI. Both ibuprofen-treated and control animals developed a progressively more-destructive disease over 12 days. Gross tibial pathology was significantly reduced in animals...

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Bibliographic Details
Published in:The Journal of infectious diseases 1986-10, Vol.154 (4), p.627-630
Main Authors: Rissing, J. Peter, Buxton, Thomas B.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone and Bones - pathology
Bones, joints and connective tissue. Antiinflammatory agents
Dinoprostone
Ibuprofen - pharmacology
Ibuprofen - therapeutic use
Male
Medical sciences
Osteomyelitis - drug therapy
Osteomyelitis - metabolism
Osteomyelitis - microbiology
Osteomyelitis - pathology
Pharmacology. Drug treatments
Prostaglandins E - metabolism
Rats
Rats, Inbred Strains
Staphylococcal Infections - drug therapy
Staphylococcal Infections - metabolism
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcus aureus - drug effects
Tibia
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Summary:Infections with Staphylococcus aureus were induced in rat tibiae without sclerosing agents. Animals received ibuprofen or 0.9% NaCI. Both ibuprofen-treated and control animals developed a progressively more-destructive disease over 12 days. Gross tibial pathology was significantly reduced in animals receiving ibuprofen for both six and 12 days postinfection. Radiographic evidence of osteomyelitis was attenuated at 12days. Geometric mean counts of S. aureus were, however, not significantly changed by ibuprofen treatment. Mean levels of prostaglandin E2 (PGE2) were highest in untreated controls. Ibuprofen treatment of infected animals was associated with a much-reduced mean value of PGE2. Ibuprofen-treated infected tibiae disclosed less PGE2 than did either ibuprofen- or NaCI-treated uninfected tibiae.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/154.4.627