Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats

The renal endothelin (ET) system, particularly the ET type B receptor, has been implicated in the regulation of sodium excretion and glomerular filtration rate (GFR). We analyzed kidney morphology and function in a rat strain characterized by complete absence of a functional ETB receptor. Due to Hir...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2001, Vol.78 (11), p.633-641
Main Authors: HOCHER, Berthold, DEMBOWSKI, Christoph, EHRENREICH, Hannelore, SLOWINSKI, Torsten, FRIESE, Sebastian T, SCHWARZ, Anja, SIREN, Anna-Leena, NEUMAYER, Hans-H, THÖNE-REINEKE, Christa, BAUER, Christian, NAFZ, Benno
Format: Article
Language:English
Subjects:
Amiloride - pharmacology
Animals
Apoptosis
Arteries - physiology
Biological and medical sciences
Blood Pressure
Bromodeoxyuridine - metabolism
Creatinine - urine
Genotype
Glomerular Filtration Rate
Homozygote
Hypertension
In Situ Nick-End Labeling
Kidney - pathology
Kidney - physiology
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Organ Size
Polymerase Chain Reaction
Rats
Receptor, Endothelin B
Receptors, Endothelin - physiology
Renal failure
Sodium - urine
Sodium Channel Blockers
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Summary:The renal endothelin (ET) system, particularly the ET type B receptor, has been implicated in the regulation of sodium excretion and glomerular filtration rate (GFR). We analyzed kidney morphology and function in a rat strain characterized by complete absence of a functional ETB receptor. Due to Hirschsprung's disease limiting lifetime in these rats, studies were performed in 23-day-old rats. Kidney size and morphology (glomerular and interstitial matrix content, glomerular size and cell density and intrarenal vascular morphology) were normal in ETB-deficient rats. There were also no evidence of altered kidney cell cycle regulation in these rats. GFR was significantly lower, by 72% (P
ISSN:0946-2716
1432-1440
DOI:10.1007/s001090000158