A histometric study in rats of the effect of the calcium antagonist amlodipine on bone healing after tooth extraction

The purpose was to investigate whether amlodipine, a second-generation calcium antagonist used for the treatment of hypertension and angina, interferes with healing of rat alveolar bone. A progressive increase in volume density of new bone filling the socket was quantified by a histometric different...

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Bibliographic Details
Published in:Archives of oral biology 2001-04, Vol.46 (4), p.375-379
Main Authors: Teófilo, J.M, Brentegani, L.G, Lamano Carvalho, T.L
Format: Article
Language:English
Subjects:
Alveolar healing
Amlodipine
Amlodipine - pharmacology
Animals
Bone Regeneration - drug effects
Calcium antagonist
Calcium Channel Blockers - pharmacology
Dentistry
Male
Osseous healing
Rats
Rats, Wistar
Tooth Extraction
Tooth Socket - drug effects
Tooth Socket - physiology
Wound Healing - drug effects
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Summary:The purpose was to investigate whether amlodipine, a second-generation calcium antagonist used for the treatment of hypertension and angina, interferes with healing of rat alveolar bone. A progressive increase in volume density of new bone filling the socket was quantified by a histometric differential point-counting method 7–42 days after tooth extraction. The results showed a 20–30% decrease in bone volume fraction in the alveolus of amlodipine-treated animals from 7 days on, in addition to a higher (7–35%) volume fraction of connective tissue and a tendency toward an increase in the volume fraction of persisting coagulum. If confirmed in humans, the knowledge of a deleterious effect of Ca-channel blockers in hindering alveolar bone healing would be important in planning oral operations involving bone tissue, including those for device implantation.
ISSN:0003-9969
1879-1506
DOI:10.1016/S0003-9969(00)00132-1