Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population

• Published in: Cancer letters 2001-04, Vol.165 (2), p.171-177
• Main Authors: Murata, Mariko, Watanabe, Masatoshi, Yamanaka, Mikio, Kubota, Yoshinobu, Ito, Haruo, Nagao, Minako, Katoh, Takahiko, Kamataki, Tetsuya, Kawamura, Juichi, Yatani, Ryuichi, Shiraishi, Taizo
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Case-Control Studies; CYP1A1 gene; Cytochrome P-450; Cytochrome P-450 CYP1A1 - genetics; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP2E1 - genetics; Genetic Predisposition to Disease; Genotype; Glutathione S-transferase; Glutathione Transferase - genetics; Humans; Japan; Male; Medical sciences; Nephrology. Urinary tract diseases; Odds Ratio; Polymorphism; Polymorphism, Genetic; Prostate cancer; Prostatic Neoplasms - genetics; Risk Factors; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(01)00398-6

Associations between genetic polymorphisms of CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 and prostate cancer (PCa) were analyzed in a case-control study of 315 individuals. The frequency of valine (Val)/valine (Val) genotypes for CYP1A1 was 11.3% in cases compared with 5.5% in controls, this polymorphism thus being associated with a significantly increased risk of PCa (odds ratio=2.4, 95% confidence interval (CI)=1.01–5.57). No links were detected between PCa and polymorphisms in other enzymes. However, the combination of CYP1A1 (Ile/Val and/or Val/Val) polymorphisms with the GSTM1 null type resulted in an OR of 2.2 (CI=1.10–4.57, 1.12–4.20, respectively). This study suggests that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population.