Subcutaneous nodular amyloidosis: A case report and review of the literature

Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck no...

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Bibliographic Details
Published in:Human pathology 2001-03, Vol.32 (3), p.346-348
Main Authors: Nguyen, Tracy U., Oghalai, John S., McGregor, David K., Janssen, Namieta M., Huston, David P.
Format: Article
Language:English
Subjects:
Adult
Amyloid - analysis
Amyloidosis
Amyloidosis - diagnosis
Amyloidosis - metabolism
Amyloidosis - pathology
Antibodies, Monoclonal
Bence Jones Protein - urine
Biological and medical sciences
Biopsy
Female
Humans
Immunoglobulin lambda-Chains - blood
Immunoglobulin M - blood
Immunohistochemistry
Male
Medical sciences
Metabolic diseases
Middle Aged
Muscle, Skeletal - pathology
Neck
nodular amyloidosis
Other metabolic disorders
primary amyloidosis
Proteinuria - urine
subcutaneous nodular amyloidosis
Tomography, X-Ray Computed
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Description
Summary:Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains. HUM PATHOL 32:346-348. Copyright © 2001 by W.B. Saunders Company
ISSN:0046-8177
1532-8392
DOI:10.1053/hupa.2001.22742