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Subcutaneous nodular amyloidosis: A case report and review of the literature
Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck no...
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| Published in: | Human pathology 2001-03, Vol.32 (3), p.346-348 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c371t-247a465bf4325ac9fb24bfd563c9237265e8c97896cfaf6b2d79be642b9593b93 |
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| cites | cdi_FETCH-LOGICAL-c371t-247a465bf4325ac9fb24bfd563c9237265e8c97896cfaf6b2d79be642b9593b93 |
| container_end_page | 348 |
| container_issue | 3 |
| container_start_page | 346 |
| container_title | Human pathology |
| container_volume | 32 |
| creator | Nguyen, Tracy U. Oghalai, John S. McGregor, David K. Janssen, Namieta M. Huston, David P. |
| description | Amyloidosis typically manifests with disseminated infiltration of multiple organ systems. Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains. HUM PATHOL 32:346-348. Copyright © 2001 by W.B. Saunders Company |
| doi_str_mv | 10.1053/hupa.2001.22742 |
| format | article |
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Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains. HUM PATHOL 32:346-348. Copyright © 2001 by W.B. Saunders Company</description><subject>Adult</subject><subject>Amyloid - analysis</subject><subject>Amyloidosis</subject><subject>Amyloidosis - diagnosis</subject><subject>Amyloidosis - metabolism</subject><subject>Amyloidosis - pathology</subject><subject>Antibodies, Monoclonal</subject><subject>Bence Jones Protein - urine</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin lambda-Chains - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - pathology</subject><subject>Neck</subject><subject>nodular amyloidosis</subject><subject>Other metabolic disorders</subject><subject>primary amyloidosis</subject><subject>Proteinuria - urine</subject><subject>subcutaneous nodular amyloidosis</subject><subject>Tomography, X-Ray Computed</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNp10M9LHDEUwPEgFd1az72VQMHbrPmdSW8itRUWPGjPIcm8YMrsZJvMtPjfm3WX9tRTcvi8R_JF6CMla0okv35edm7NCKFrxrRgJ2hFJWddzw17h1aECNX1VOtz9L7Wn41RKeQZOqe0aSX0Cm0eFx-W2U2Ql4qnPCyjK9htX8achlxT_YJvcHAVcIFdLjN209CuvxP8wTni-RnwmGYobl4KfECn0Y0VLo_nBfpx9_Xp9nu3efh2f3uz6QLXdO6Y0E4o6aPgTLpgomfCx0EqHgzjmikJfTC6NypEF5VngzYelGDeSMO94Rfo6rB3V_KvBepst6kGGMfDN6zWhGhm-gavDzCUXGuBaHclbV15sZTYfUC7D2j3Ae1bwDbx6bh68VsY_vljsQY-H4GrwY2xuCmk-tcZqRlVTZmDgpahxSq2hgRTgCEVCLMdcvrvE14B6NiMMw</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Nguyen, Tracy U.</creator><creator>Oghalai, John S.</creator><creator>McGregor, David K.</creator><creator>Janssen, Namieta M.</creator><creator>Huston, David P.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Subcutaneous nodular amyloidosis: A case report and review of the literature</title><author>Nguyen, Tracy U. ; 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Rarely, amyloidosis may be localized. We report a patient with localized subcutaneous nodular amyloidosis, without systemic amyloid involvement or myeloma, whose presenting symptom was multiple discrete neck nodules. Immunohistochemical analysis showed the amyloid deposits to be derived from lambda light chains. Twenty-four month follow-up showed minimal disease progression. A literature review showed only 5 reported cases of subcutaneous nodular amyloidosis. This is the first description of a patient with subcutaneous nodular amyloidosis derived from lambda light chains. HUM PATHOL 32:346-348. Copyright © 2001 by W.B. Saunders Company</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11274647</pmid><doi>10.1053/hupa.2001.22742</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0046-8177 |
| ispartof | Human pathology, 2001-03, Vol.32 (3), p.346-348 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Amyloid - analysis Amyloidosis Amyloidosis - diagnosis Amyloidosis - metabolism Amyloidosis - pathology Antibodies, Monoclonal Bence Jones Protein - urine Biological and medical sciences Biopsy Female Humans Immunoglobulin lambda-Chains - blood Immunoglobulin M - blood Immunohistochemistry Male Medical sciences Metabolic diseases Middle Aged Muscle, Skeletal - pathology Neck nodular amyloidosis Other metabolic disorders primary amyloidosis Proteinuria - urine subcutaneous nodular amyloidosis Tomography, X-Ray Computed |
| title | Subcutaneous nodular amyloidosis: A case report and review of the literature |
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