Endoscopic implantation of Plexiglas (PMMA) microspheres for the treatment of GERD

Background: A gelatinous implant containing polymethylmethacrylate (PMMA) beads is successfully used to augment the diminished thickness of the chorium in patients with skin defects and wrinkles. The aim of the present study was to determine whether submucosal injection of PMMA microspheres into the...

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Published in:Gastrointestinal endoscopy 2001-04, Vol.53 (4), p.423-426
Main Authors: Feretis, Christos, Benakis, Paul, Dimopoulos, Christos, Dailianas, Apostolos, Filalithis, Panayotis, Stamou, Konstantinos M., Manouras, Andreas, Apostolidis, Nickolaos
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Diseases of the digestive system
Esophagoscopy - methods
Esophagus - chemistry
Esophagus - diagnostic imaging
Female
Gastroesophageal Reflux - therapy
Humans
Hydrogen-Ion Concentration
Injections, Subcutaneous
Male
Medical sciences
Microspheres
Middle Aged
Polymethyl Methacrylate - administration & dosage
Polymethyl Methacrylate - therapeutic use
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Ultrasonography
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Summary:Background: A gelatinous implant containing polymethylmethacrylate (PMMA) beads is successfully used to augment the diminished thickness of the chorium in patients with skin defects and wrinkles. The aim of the present study was to determine whether submucosal injection of PMMA microspheres into the lower esophageal folds decreases the severity of symptoms and acid reflux in patients with GERD. Methods: Endoscopic submucosal implantation of PMMA was carried out in 10 patients with GERD who were either refractory to or dependent on proton pump inhibitors. Symptom severity score, 24-hour pH monitoring, upper GI endoscopy, and EUS were performed to evaluate the efficacy of implantation. Results: A significant decrease in the symptom severity score and mean total time with esophageal pH less than 4 was noted after the implantation of PMMA ( p < 0.05). Seven of 10 patients were taking no medication after PMMA implantation. There were no serious procedure-related complications. Conclusions: Endoscopic implantation of PMMA into the submucosa of the lower esophageal folds may be a new method for treating GERD. Further studies are required to determine the long-term efficacy of the procedure. (Gastrointest Endosc 2001;53:423-6.)
ISSN:0016-5107
1097-6779
DOI:10.1067/mge.2001.113912