Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat

Petroleum ether, chloroform, ethanol and distilled water extracts of the aerial parts of the plant Rivea hypocrateriformis (Convolvulaceae) were tested for antiimplantation and pregnancy interruption properties in female albino rats. Among these, the ethanol extract was found to be most effective in...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-03, Vol.74 (3), p.245-249
Main Authors: Shivalingappa, H., Satyanarayan, N.D., Purohit, M.G.
Format: Article
Language:English
Subjects:
Abortifacient Agents - isolation & purification
Abortifacient Agents - pharmacology
Animals
Biological and medical sciences
Contraceptive Agents - isolation & purification
Contraceptive Agents - pharmacology
Female
General pharmacology
India
Medical sciences
Medicine, Ayurvedic
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Pregnancy
Rat
Rats
Rivea hypocrateriformis
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Summary:Petroleum ether, chloroform, ethanol and distilled water extracts of the aerial parts of the plant Rivea hypocrateriformis (Convolvulaceae) were tested for antiimplantation and pregnancy interruption properties in female albino rats. Among these, the ethanol extract was found to be most effective in causing significant antiimplantation and interruption of early pregnancy. The antifertility activity of ethanol extract was reversible on exogenous administration of hydroxy progesterone. However, the same ethanol extract was found to be ineffective in interruption of late pregnancy. Among the four extracts subjected to preliminary phytochemical screening, the active ethanol extract showed positive tests for alkaloids, glycosides, saponins, tannins and phenolic compounds.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00372-X