The use of genetic complementation in the study of eukaryotic macromolecular evolution: rate of spontaneous gene duplication at two loci of Drosophila melanogaster

Gene duplications must play an important role in the evolutionary development of living organisms. Presented here is a general scheme that uses complementary alleles to isolate gene duplications in diploid organisms. The technique was used in Drosophila melanogaster to assess the rate of spontaneous...

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Bibliographic Details
Published in:Journal of molecular evolution 1986, Vol.23 (2), p.159-167
Main Authors: SHAPIRA, S. K, FINNERTY, V. G
Format: Article
Language:English
Subjects:
Alleles
Animals
Biological and medical sciences
Biological Evolution
Crosses, Genetic
Drosophila melanogaster - genetics
Female
Fundamental and applied biological sciences. Psychology
Genetic Complementation Test
Genetics of eukaryotes. Biological and molecular evolution
Male
Mutation
Phenotype
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Summary:Gene duplications must play an important role in the evolutionary development of living organisms. Presented here is a general scheme that uses complementary alleles to isolate gene duplications in diploid organisms. The technique was used in Drosophila melanogaster to assess the rate of spontaneous gene duplication at two loci, maroon-like and rosy. The results indicate that the rate of duplication of the maroon-like locus is on the order of 2.7 X 10(-6); that the rate of duplication of the rosy locus is approximately 1.7 X 10(-4); and that duplication occurs in males, suggesting that there may actually be two modes of gene duplication in Drosophila melanogaster.
ISSN:0022-2844
1432-1432
DOI:10.1007/BF02099910