Risk factors for typhoid fever in the Mekong delta, southern Viet Nam: a case-control study

In order to identify risk factors for typhoid fever in a highly endemic area, we undertook a case-control study in the Mekong delta, Viet Nam. Cases were 144 consecutive patients admitted to hospital with blood culture-confirmed typhoid fever. Two controls (1 in the hospital and 1 in the community)...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2001, Vol.95 (1), p.19-23
Main Authors: Luxemburger, Christine, Duc, Chau Minh, Lanh, Mai Ngoc, Wain, John, Hien, Tran Tinh, Simpson, Julie A., Kam, Le Hoang, Tu Thuy, Nguyen Thi, White, Nicholas J., Farrar, Jeremy J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Case-Control Studies
Child
Child, Preschool
Female
Hospitalization - statistics & numerical data
Human bacterial diseases
Humans
Infant
Infant, Newborn
Infectious diseases
Logistic Models
Male
Medical sciences
Middle Aged
Pilot Projects
Prevalence
Risk Factors
Salmonella typhi
Tropical medicine
typhoid fever
Typhoid Fever - epidemiology
Viet Nam
Vietnam - epidemiology
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Summary:In order to identify risk factors for typhoid fever in a highly endemic area, we undertook a case-control study in the Mekong delta, Viet Nam. Cases were 144 consecutive patients admitted to hospital with blood culture-confirmed typhoid fever. Two controls (1 in the hospital and 1 in the community) were chosen for each case. Standardized interviews were conducted with questions regarding recent contact with a typhoid fever patient, eating habits, hygiene and socio-economic level. Cases were more likely to have been in contact with a patient with typhoid fever than hospital controls (adjusted odds ratio (OR) = 5 · 2, 95% confidence interval (95%CI) 1 · 7–15 · 9) or community controls (adjusted OR = 11 · 9, 95%CI 2 · 3–60 ·7); 11% and 14% of typhoid fever cases (compared to hospital or community controls, respectively) were attributable to recent contact with a patient with this disease. These findings suggest that strategies directed towards the persons in contact with a patient might reduce the incidence of secondary cases of typhoid fever.
ISSN:0035-9203
1878-3503
DOI:10.1016/S0035-9203(01)90318-9